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Indications and Dosage
Oral
Iron-deficiency anaemia Adult: Up to 1.6 g daily, equivalent to 80 mg iron.
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Contraindications
Patients receiving repeated blood transfusions. Oral and parenteral iron therapy should not be used together.
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Special Precautions
Haemochromatosis, haemoglobinopathies; existing GI diseases eg. inflammatory bowel disease, intestinal strictures, diverticulae. Liquid iron preparations should be well-diluted and swallowed through a straw to prevent teeth discolouration.
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Adverse Reactions
GI discomfort such as nausea, vomiting, diarrhoea, constipation, epigastralgia.
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Drug Interactions
Compounds containing calcium, magnesium, bicarbonates, carbonates, oxalates, or phosphates may impair iron absorption by forming insoluble complexes. Response to iron may be delayed when used with systemic chloramphenicol. Iron may decrease absorption of cefdinir, biphosphonates, entacapone, fluoroquinolones, levodopa, methyldopa, mycophenolate mofetil, penicillamine, levothyroxine. Absorption of both agents may be diminished when iron is taken with zinc salts, tetracyclines (separate admin by 2-3 hr), acetohydroxamic acid.
Potentially Fatal: Toxic complexes may form with dimercaprol. |
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Action
Description:
Mechanism of Action: Iron proteinsuccinylate is an iron compound for the oral treatment of iron deficiency anemia. |
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